During organogenesis, cells face two major challenges. First, progenitor cells need to maintain a balance between self-renewal and differentiation to ensure the generation of the correct number of cell types. Second, differentiated cells need to maintain appropriate organization to confer organ functionality. Many human birth defects are due to failure in cellular differentiation, and many human diseases are caused by defects in organ maintenance. My lab is interested in understanding the molecular and cellular mechanisms that regulate cell differentiation and tissue maintenance. Understanding these processes will inform better strategies to promote organ regeneration and repair. We use zebrafish as a model system, because molecular and genetic analyses can be combined with high-resolution in vivo imaging and large-scale small molecule screens.