Senior Instructor, Departments of Cell Biology & Anatomy, Biochemistry & Molecular Biology
Cumming School of Medicine
University of Calgary
HM 272b, 3330 Hospital Drive NW
Calgary, AB, T2N 4N1
My work focuses on two inter-related areas of developmental neurobiology: 1) pattern formation within the developing central nervous system of the vertebrate embryo and 2) the ontogeny of distinct neuronal systems. More specifically, I am interested in defining the cellular and molecular mechanisms involved in setting up positional information along the rostral-caudal and medial-lateral axis within developing mes/metencephalic derivatives. In addition, I have recently begun to investigate the molecular cues involved in the differentiation of specific neuronal cell types and establishment of neuronal circuitry within the developing cranial sensory system.
I use the chick embryo as a model system in which to explore both of these issues and utilize a multidisciplinary approach which combines techniques in molecular biology, electroporation and retroviral-mediated gene transfer, microsurgery, cell and tissue culture, anterograde labelling, as well as immunohistochemistry.
Identification of key regulators of first-order relay sensory neurons in the developing vertebrate brainstem
Other Area(s) of Research:
Pattern formation within the developing central nervous system of the vertebrate embryo