Associate Professor, Department of Paediatrics
University of Calgary
3330 Hospital Drive NW
Calgary, AB T2N 4N1
Our lab is interested in understanding the molecular mechanisms that regulate beta cell mass and function, using pregnancy as the model. We have found that intact prolactin receptor signaling is required for normal glucose homeostasis and beta cell mass expansion during pregnancy.
We will now examine 1) whether beta-cell neogenesis occurs during pregnancy, 2) the signalling pathways that are required for the increase in beta-cell mass during pregnancy, and 3) whether pregnancy hormones can improve glucose homeostasis in animal models of type 1 and type 2 diabetes, or the outcomes of islet transplantation.
Regulation of beta cell proliferation and function in animal models of diabetes
Other Area(s) of Research:
Improving metabolic outcomes in children with diabetes and/or obesity