University of Calgary
UofC Navigation

Christophe Altier

Position: 

Assistant Professor, Department of Physiology and Pharmacology,
Cumming School of Medicine

Phone: 
(403) 220-7549
Address: 

Cumming School of Medicine
HSC 1665
3330 Hospital Drive NW
Calgary AB T2N 4N1

Research Activities: 

My laboratory investigates the molecular plasticity of pain sensing neurons that underlies peripheral sensitization of the nociceptive system during tissue inflammation.  A hallmark of acute inflammation is a hyperexcitability of the sensory Dorsal Root Ganglion (DRG) neurons at the periphery, a phenomenon also called peripheral sensitization which can lead to chronic pain. It is well established that pro-inflammatory mediators released by different cell types (immune cells, microglia, or astrocytes) lower the threshold of activation of sensory neurons thereby triggering peripheral sensitization. Among a large variety of ion channels found in DRG neurons, my lab examines the regulation of the Transient Receptor Potential Channels, that participate in the regulation of Ca2+ homeostasis, and are central players in inflammatory pain. Our lab uses a combination of molecular biological, electrophysiological, imaging and behavioural assessment techniques to determine how the activity and expression of these channels is altered in inflammatory pain, and identify novel means to normalize their function.  

Publications: 
Degrees: 
  • Ph.D. (Doctor of Philosophy)