Professor, Departments of Oncology, Biochemistry & Molecular Biology, Medical Genetics; Director, ESTM Facility; Coordinator, MBT Program
Cumming School of Medicine
HM 428, 3330 Hospital Drive NW
Calgary, AB, T2N 4N1
My research program revolves around the derivation, expansion, differentiation and genetic manipulation of mouse and human pluripotent stem cells (PSCs), including embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. Over the past several years we have been developing bioprocesses for generating bone and cartilage tissue from stem cells for transplantation. An important feature of our research is that we have developed methods for expanding and differentiating murine and human PSCs as aggregates in suspension bioreactors (SSBs). Recently, we have discovered that fluid shear stress in SSBs induces pluripotency and significantly increases the efficiency of generating iPS cells.
Implantation serine proteinases
Other Area(s) of Research:
Recombineering and bacteriophage mediated gene targeting; ES cell differentiation