Professor, Departments of Radiology, Clinical Neurosciences and Physiology & Pharmacology
3280 Hospital Drive NW
MRI and optical imaging of brain physiology
Primary Area of Research:
We develop and apply a range of technologies to study oxygen regulation in brain and to use oxygenation as a marker of disease processes. We also use MR microscopy and quantified MRI to study white matter degeneration, vascular adaptation and molecular imaging in animal models. We have developed methods to non-invasively study angiogenesis in brain in response to chronic low oxygen - such as may occur in stroke, MS and high altitude medicine. Currently, we are using MRI, and near-infrared spectroscopy to study hypoxia, and vascular responses in traumatic brain injury, epilepsy, MS and stroke in both patient studies and animal models.
We are developing and applying a range of technologies to study oxygen levels in tissues and how these relate to disease processes. MR microscopy and quantified MRI are also being used to study white matter degeneration, vascular adaptation and molecular imaging in animal models. We have developed methods to study non-invasively angiogenesis in brain in response to chronic low oxygen—such as may occur in stroke, MS and high altitude medicine. Animal models include stroke, epilepsy, cancer and MS. We are translating optical technologies to the clinic in areas such as epilepsy, stroke, psychiatry and sports medicine. By using a combination of imaging and histological studies, we aim to determine how the brain adapts to hypoxia, and to apply that knowledge to treatment of conditions such as stroke and migraine.
Research: Role of hypoxia and oxygen in supporting energy metabolism in normal and diseased tissue (stroke, high altitude, cancer), angiogenesis, brain physiological adaptation, MR imaging and spectroscopy, NIR optical spectroscopy, NMR microscopy, correlation of cartilage imaging with structure, white matter imaging