Assistant Professor, Depts of Pathology & Laboratory Medicine, Oncology, Clinical Neurosciences
Cumming School of Medicine
University of Calgary
3330 Hospital Dr NW
Calgary, AB T2N 4N1
Primary Area of Research:
Dr. Chan’s independent research program applies concepts from developmental neurobiology to further understand mechanisms of disease in brain tumorigenesis. Her lab examines the intersection of growth factor signaling and intrinsic determinants such as transcription factor function in cell fate determination and proliferation in neural development and cancer. Her work uses techniques of somatic transgenesis to introduce genes of interest into neural stem and progenitor cells to model tumorigenesis, and is supplemented by in vitro studies using brain tumour initiating cells (BTICs) derived from patient material. Current research projects include defining the role of CIC in oligodendrogliomas, the role of proneural genes in oligodendrogliomas and astrocytomas, and mech. She is also involved in several collaborative multi-institutional projects to molecularly characterize a variety of pediatric and adult brain tumours.
Outside of her role as an independent investigator, she has established tissue resources that have contributed to the research efforts of the greater research community by directing the Neuro-Oncology tumour banking program at FMC and launching a Pediatric Oncology tumour banking program at ACH. These programs collect tissues and fluids from cancer patients, and culture cancer stem cells from participating patients. These resources have been the foundation for her own studies as well as collaborative research projects locally, nationally, and internationally.