Assistant Professor in the Department of Paediatrics
Cumming School of Medicine
3330 Hospital Drive NW
Calgary, AB T2N 4N1
infantile spasms; prevention of the development of epilepsy following atypical febrile seizures in children
The principal foci of our laboratory are 1) to find a cure for infantile spasms and 2) to prevent the development of epilepsy following atypical febrile seizures in children.
My research has focussed on the development and characterization of models of paediatric epilepsy syndromes. I have so far developed a model of temporal lobe epilepsy following atypical febrile seizures and a model of symptomatic infantile spasm syndrome. In a collaborative approach, our laboratory utilizes long-term EEG and behavioral assessments (Barnes maze, Morris water maze, social chamber, open field) in conjunction with molecular, biochemical, pharmacological and electrophysiological (in-vitro field potentials and whole- cell patch clamp) techniques to understand the factors underlying seizure/epileptogenesis in the animal models. Our overall goal is to use this increased understanding derived from the animal models to guide the discovery of novel targets for therapeutic intervention that can be rapidly translated to clinical practise for which there is an urgent need.