Professor, Department of Psychology; Adjunct Professor, Department of Cell Biology & Anatomy
Department of Psychology
Admin 28, 2500 University Drive, NW
Calgary AB T2N 1N4
Discovery of mechanisms for recovery after neonatal brain injury
Other Area(s) of Research:
The role of synaptic zinc in the brain
1. Cerebral Cortical Development and Plasticity: Studies are designed to elucidate the processes involved in the development of the mammalian cerebral cortex. The organization of the cerebral cortex is not fixed but is plastic, meaning that it is continuously modified by experience (e.g. sensory inputs, learning, drugs/hormones, injury, etc.) throughout our lifetime. The synaptic connectivity of the cortex is particularly malleable during early periods of postnatal development. Research activities, funded by Natural Sciences and Engineering Research Council of Canada, are directed toward identifying the molecules and mechanisms that are responsible for mediating experience-dependent plasticity in the cerebral cortex. We use cellular, molecular and behavioural approaches in animal models in order to understand these phenomena.
2. Recovery after Brain Injury: We are currently engaged in research that is directed toward understanding the mechanisms of neuronal injury, and recovery of function after brain injury. This research program, funded by the Canadian Institutes of Health Research assesses anatomical and behavioural indices of functional recovery following traumatic brain injury or stroke induced in the neonate. In particular, we are interested in identifying molecules that attenuate cell death and potentiate neuronal survival and regeneration.