Dave Schriemer

Our laboratory maintains a fundamental research program in structural proteomics. We are interested in understanding how governing principles behind molecular interactions serve to organize protein function at a scale beyond that of the individual protein. Using the tools of proteomics, structural biology and computation modeling, we study structure-function relationships in large multicomponent protein systems, with a view to understanding how function can be regulated at this “mesoscale”. To this end, our group specializes in biological mass spectrometry. We are actively involved in developing the technology as a key provider of modeling data and work collaboratively to move structure determination closer to cellular-level activity. A high level of expertise in proteomics allows us to explore collaborative translational research opportunities in the area of brain cancer, autism and celiac disease.