Marie-Claire Arrieta

My research interests lie in the role of the intestinal microbiota in the development of immune-mediated and metabolic pediatric diseases. My approach for these studies is to apply multi-omic techniques, including microbiome high-throughput16S sequencing, metabolomic (ULPC-MS/MS) and transcriptomics, in large-scale pediatric population-based studies. From the results from these studies, I apply my training in mucosal immunology and physiology to answer mechanistic question in animal models of disease, including IBD and asthma. Utilizing these tools I plan to address the general research question of how metabolites originated from alterations in early-life intestinal microbiota contribute to intestinal and extra-intestinal disease.